A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137

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A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137

Retinoic acid-related orphan receptor alpha gene (RORa) and the microRNA MIR137 have both recently been identified as novel candidate genes for neuropsychiatric disorders. RORa encodes a ligand-dependent orphan nuclear receptor that acts as a transcriptional regulator and miR-137 is a brain enriched small non-coding RNA that interacts with gene transcripts to control protein levels. Given the m...

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Sex Hormones in Autism: Androgens and Estrogens Differentially and Reciprocally Regulate RORA, a Novel Candidate Gene for Autism

Autism, a pervasive neurodevelopmental disorder manifested by deficits in social behavior and interpersonal communication, and by stereotyped, repetitive behaviors, is inexplicably biased towards males by a ratio of ∼4∶1, with no clear understanding of whether or how the sex hormones may play a role in autism susceptibility. Here, we show that male and female hormones differentially regulate th...

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the relationship between learners critical thinking ability and their performance in the reading sections of the tofel and ielts test

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2014

ISSN: 2045-2322

DOI: 10.1038/srep03994